（譯文版權所有，轉載或引用請注明出處。）

低氘水對體內腫瘤發育作用的雙重性（2）

Н.В雅閣洛娃     莫斯科人體形態研究所

B16黑色素瘤是具有高轉移潛力的惡性腫瘤。靜脈注入放射同位素后，腫瘤轉移研究發現了兩個實驗組的差異。在腫瘤接種前一個月開始喂飼低氘水的小鼠組中發現，腫瘤肺轉移數量顯著低于，腫瘤接種后才開始喂飼低氘水的小鼠組和對照組的小鼠。在腫瘤接種后才開始喂飼低氘水的小鼠組中，與對照組比較腫瘤轉移數量沒有統計學上的顯著差異。

總之，低氘水顯示了對腫瘤發展過程的雙重效應：在腫瘤發展時喂飼低氘水對壽命和腫瘤轉移，以及抑制腫瘤生長和轉移都沒有積極影響，而在腫瘤發展之前喂飼低氘水小鼠的存活率提高。

已證實了的低氘水對腫瘤發展過程的積極效應。

Somlyai G, et al. Naturally occurring deuterium is essential for the normal growth rate of cells. FEBS Lett. 1993; 317:1–4.

? Somlyai G, et al. The biological effects of deuterium-depleted water, a possible new tool in cancer therapy. Zeitschrift für Onkologie (ger). Journal of Oncology. 1998; 30:91–94.,

? Bader Y, Hartmann J, Horvath Z, Saiko P, Grusch M, Madlener S, et al. Synergistic effects of deuterium oxide and gemcitabine in human pancreatic cancer cell lines. //Cancer Lett 2008; 259:231-239.

? Cong FS, et al. Deuterium-Depleted Water Inhibits Human Lung Carcinoma Cell Growth by Apoptosis. Exp Ther Med. 2010; 1:277–283.

? Miric? RE. Deuterium-depleted water in cancer therapy. Environmental EEMJ 2010;9:1543-1545.,

? Kovacs A, et al. Deuterium depletion may delay the progression of prostate cancer. J Cancer Ther. 2011; 2:548–556.

Cong F., Zhang Y., Sheng H., Ao Z., Zhang S., Wang J. Deuterium-depleted water inhibits human lung carcinoma cell growth by apoptosis // Exp Ther Med. 2010 Mar-Apr; 1(2): 277–283.,

? Gy?ngyi Z, et al. Deuterium-depleted Water Effects on Survival of Lung Cancer Patients and Expression of Kras and Bcl2 Genes in Mouse Lung. Nutr Cancer. 2013; 65:240–246. (2013).,

? Gyongyi Z, Somlyai G. Deuterium depletion can decrease the expression of c-myc, Ha-ras and p53 gene in carcinogen-treated mice. In Vivo. 2000; 14:437–439.,

? Wang H, Zhu B, He Z, Fu H, Dai Z, Huang G, et al. Deuterium-depleted water (DDW) inhibits the proliferation and migration of nasopharyngeal carcinoma cells in vitro. Biomed Pharmacother 2013; 67:489-496.

低氘水的抗腫瘤作用機理

代謝理論